An In vitro fertilization (IVF) procedure from even the best fertility centre in Hyderabad cannot guarantee a 100% success rate. It is often due to the embryo’s failure to implant in the uterus and causes frustration amongst individuals and couples. If you’ve had more than one failed IVF treatment in Hyderabad or your doctor informs you of a poor prognosis for IVF, the next best option available to you is a technique known as assisted hatching.

What Is Assisted Hatching?

During the initial stages of development in the egg, after being fertilized in a laboratory, the embryo is observed in the zona pellucida (a layer of proteins). For the embryo to successfully implant into the uterine lining, it has to hatch out of the zona pellucida and attach to the nearby walls of the uterus. When the experts noticed that embryos with a thin zona pellucida had achieved a higher rate of implantation during IVF, they developed a new lab technique known as assisted hatching.

Under this technique, an embryologist carefully observes the embryo until the third day of its development when it contains at least six to eight cells. At that time, the embryologist creates a tiny hole in the zona pellucida using micromanipulation under a microscope. With the help of a holding pipette, the embryos are then stabilized while a small laser creates a small hole in the zona pellucida. Once this procedure is over, the embryos are then returned to the incubator to complete their remaining stages of development.

Who Can Opt for Assisted Hatching With IVF?

Assisted hatching is recommended to those couples who have a poor prognosis as their embryos do not contain sufficient energy to complete the hatching process. If you take consultation from the doctors at the best fertility centre in Hyderabad, they may also advise this procedure for women with:

  • Advanced maternal age (or over 38 years)
  • More than two failed IVF cycles
  • Poor quality of embryos

IVF Assisted Hatching Methods

The three methods for IVF Assisted Hatching are:

  • Laser-Assisted Hatching
  • Acid Tyrode’s Solution
  • Partial Zona Dissection (PZD)

Of these, laser-assisted hatching is the most commonly used modern approach. With the help of specialized software, the embryologists first measure the thickness of the zona pellucida of the patient and then adjust the position, intensity, and focus of the lasers to create a hole. It is a relatively safer method for assisted hatching as it offers more speed and precision to the embryologists.

Acid Tyrode’s solution is a traditional method that involves exposing a small amount of acid onto the zona pellucida using a micro-needle through direct contact. In the Partial zona dissection (PZD) method, a cross-hatched slit in the zona pellucida is created with the help of a holding pipette and a micro-needle. However, most clinics have shifted to the modern approach of laser-assisted hatching because of its efficiency and accuracy.

Does Assisted Hatching Increase the Success Rate of IVF?

Assisted hatching does help in increasing the chances of IVF success, especially in patients with poor prognosis. Several parents have benefited from such IVF treatment in Hyderabad. But it is important to remember here that assisted hatching is a difficult technique. So, the success of this treatment with IVF depends on the embryologist’s experience and technique. It is advisable to check with your fertility clinic about their procedure success rate in the past.

How Safe Is Assisted Hatching With IVF?

As mentioned earlier, assisted hatching is a difficult technique that requires a great level of experience and technique from the experts at the fertility clinic. There are certain complications associated with this procedure including damage to the embryo, damage to the patient’s blastomeres, and even twin pregnancy. That is why we recommend consulting with only the best fertility centre in Hyderabad that offers the required expertise.

There are clinical studies that have shown an increase in the success of implantation of transferred embryos with assisted hatching. Consult with the top fertility centre in your city and get one step closer to your dream of parenthood.